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Exploring Methylation Clocks and Age Measurement
This chapter explores the relevance of methylation clocks in measuring epigenetic age compared to traditional markers. The discussion includes personal experiments, media attention on age reversal claims, and skepticism surrounding conventional standards.
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🕑 Timestamps:
0:00:00 – Intro
0:00:57 – The ‘Rejuvenation Olympics’ Leaderboard
0:02:47 – Who Is Bryan Johnson?
0:09:05 – How Bryan Transitioned From Near-Billionaire Tech Entrepreneur To Experimental Biohacker
0:13:07 – Why Bryan Johnson's Johnson Is The Most Measured Johnson On Earth
0:18:14 – Eight Sleep (The Most Impactful Sleep Enhancing Device I Have Ever Used)
0:21:56 – Erection Quality Metrics And Issues With Tracking
0:23:36 – The Exotic Drugs In Bryan Johnson's "Don't Die" Protocol
0:27:34 – "Don't Die" (but take experimental drugs?) | Grilling Bryan Johnson On His Choice Of Drugs
0:30:58 – Bryan’s View On Hair Transplants, Facial Fillers, Plastic Surgery, Or Anything Surgical That Conflates The Visual Perception Of A Person’s Age
0:33:40 – "HGH Was Catastrophic" | Bryan’s Experience With HGH And Thymus Rejuvenation
0:36:52 – Rapamycin For ‘Anti-Aging’
0:40:23 – Why Bryan Tried Follistatin Gene Therapy, IV Stem Cells, And Is Using 17α-Estradiol And Metformin
0:45:13 – Power Outage
0:45:14 – Bryan Johnson Risks Ruining His Perfect Sleep Score To Try A Gorilla Mind Energy Drink
0:49:22 – Dissecting The Results Of Bryan Johnson's $25,000 Follistatin Gene Therapy
1:06:38 – What Is Bryan’s ‘Blueprint’ Protocol?
1:15:33 – Bryan Reacts To Elon Musk Saying He Looked Better Before
1:23:54 – Bryan Reacts To Chuando Tan (58 years old) - Does Biohacking Even Work?
1:30:15 – How To Become A Centenarian (100+ Years Old)
1:32:59 – The Most Impactful Of The Exotic Biohacks Bryan Has Tried
1:39:59 – Why Bryan Went On TRT, And Then Came Off
1:44:54 – Does Bryan Have Financial Upside In Any Of The Companies He Promotes That He Hasn’t Explicitly Stated Are His Companies?
1:46:26 – Why 15% Of Bryan’s Daily Calories Come From Extra Virgin Olive Oil (EVOO)
1:48:43 – Diary Of A CEO Podcast Quote About EVOO | “It’s Better Than Ozempic”
1:57:52 – Bryan Psychoanalyzes Me
2:07:11 – Marek Health (Preventive Medicine, HRT, & Rigorous Bloodwork Analysis)
2:13:37 – Bryan Dissects My Mindset
2:16:15 – Determining What Content Creators To Learn From
2:19:11 – The Understanding Of Myostatin Inhibiting Muscle Growth Over The Years
2:22:32 – The Challenges Of Being A Night Owl And Not Sleeping Enough
2:26:01 – Chasing Success, Even When It Starts To Eat Into The Rest Of Your Life
2:32:52 – Imposter Syndrome
2:35:27 – If I Could Change One Thing About How The Medical System Works
2:38:37 – Influencer Burnout
2:40:10 – My Ancestry And Nature Vs. Nurture
2:44:37 – Jordan Peterson's Opinion Of Bryan Johnson’s Life Philosophy
2:53:13 – Thoroughly Dissecting Bryan’s New Supplement Line, His Motivations Behind Starting It, And His Claims Made About Its Efficacy
3:34:36 – Bryan Stating On Diary Of A CEO That Everybody Should Know Their Weight, Speed Of Aging, And Duration Of Nighttime Erections
3:36:33 – The Legitimacy And Utility Of Age Clocks, And When They Can Be Helpful Vs. Harmful
3:58:52 – Bryan’s Use Of Thyroid Hormone Replacement Since He Was 21 Years Old
4:01:14 – Is Drinking Your Own Urine A Dark Horse Biohack? Bryan’s Reaction
4:04:03 – If Bryan Could Go Back In Time Before He Sold His Company For $800 Million, What Would He Tell Himself
4:08:45 – How Does Bryan Factor In Social Loneliness Outranking Essentially Everything For Accelerating Dying
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