One of the things metabolically diaterially environmentally that are making people need more b6 than they might think. My mom has had a kidney stone and her oxalate levels were through the roof, so my guess is she needed even more b6. I was getting some twitching problems and I found that I need 25 to 50 milligrams of b6 as p5p to stop the twitching. A lot of people report consistently everyone who takes high b6 has like really intense lucid dreams.