12min chapter

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Burying trees to lock up carbon, notorious ‘Alzheimer’s gene’ fuels hope, and a book on virtual twins

Science Magazine Podcast

CHAPTER

Unpacking ApoE4 and Alzheimer's Risk

This chapter examines the ApoE4 genetic variant and its strong connection to Alzheimer's disease risk, highlighting its historical research evolution from heart disease to neurodegenerative focus. It discusses the implications of ApoE4 on brain function, amyloid plaque production, and ongoing innovative treatment strategies, including gene therapy and clinical trials. The chapter also explores the persistent presence of ApoE4 in the population and transitions to a discussion on climate change solutions.

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