Understanding High-Grade Gliomas in Children

Today, we're talking with Stanford neuro-oncologist, Michelle Monje. This is actually the third time we've had Michelle on the show, in part because she's been a pioneer of three exciting frontiers in neuroscience — so far! 

This week, we're going to talk about cancer neuroscience. Michelle founded this new field with her discovery that deadly brain tumors not only link up physically with the healthy brain tissue surrounding them, but the cancers actually need the brain's electrical activity to grow and spread.

It turns out that many cancers — not only in the brain — depend on nervous system innervation for their survival. Understanding this dependent relationship better may present an exciting new line of attack for oncology. 

Join us to learn more!

News coverage

• Brain tumors caused by normal neuron activity in mice predisposed to such tumors
• Brain tumors form synapses with healthy neurons, Stanford-led study finds
• Deadly brain cancers act like 'vampires' by hijacking normal cells to grow
• Engineered immune cells target broad range of pediatric solid tumors in mice

Relevant Publications

• Glioma synapses recruit mechanisms of adaptive plasticity
• Glioblastoma remodelling of human neural circuits decreases survival
• Electrical and synaptic integration of glioma into neural circuits
• Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma
• Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

Review Articles

• The neuroscience of cancer
• Cancer hallmarks intersect with neuroscience in the tumor microenvironment
• Roadmap for the Emerging Field of Cancer Neuroscience

Episode Credits
This episode was produced by Michael Osborne, with production assistance by Morgan Honaker, and hosted by Nicholas Weiler. Art by Aimee Garza.

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