Zindel Segal – Mindfulness and Depression
Mind & Life
The Sub-Genual Interiors of Depression
The serotonin hypothesis around depression is kind of being overturned or it's not as solid as they thought, maybe just to flesh out for the audience. I think that that hypothesis developed because many effective antidepressants acted on the serotonin system in a way that increased the amount of serotonin available for processing. So therefore it made sense to think that maybe the problem was some sort of deficit. But when you actually look at studies of changes in serotonin and the time interval by which antidepressants start to have their effect, it could be that serotonin changes happened a lot sooner than four to six weeks usually required before you see someone starting to improve. These are sort of discrepancies in the narrative and that's just one feature of the
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