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Stephan Guyenet, PhD – Overeating, Fat Mass Regulation & Energy Homeostasis

Sigma Nutrition Radio

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Metabolic adaptations and strategies for weight maintenance

This chapter discusses the metabolic adaptations that occur with weight loss, focusing on the role of leptin and the hypothalamus. It explores the starvation response initiated by reduced leptin levels, including increased hunger, decreased thyroid hormone signaling, and altered muscular efficiency. The chapter concludes with strategies to mitigate these adaptations and support weight maintenance goals.

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