The Diversity of Actions of Melatonin

Melatonin helps indirectly catalyze SOD through activating sirtuin-sert three. Does it activate it through transcription factor like NRF2 pathway through the antioxidants response elements? Or I couldn't find that in the literature. Well, certainly it's genomic effect on the enzyme that regulates the synthesis of melatonin glutamil cysteine-tin phase. The other thing that often confounds scientists is that the melatonin concentration is not that high within cells with the exception of mitochondria.