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EP. 58: YOUR BRAIN ON DEPRESSION: DR. JOHN KRYSTAL ON ANTIDEPRESSANTS, PSYCHEDELICS, AND KETAMINE THERAPY

Bounce! Conversations with Larry Weeks

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Depression and GABA in the Brain

The main information highway of the brain, the glutamate system, turned out to be affected in depression. Bruce McEwen identified that when animals are stressed for a long time, severe stress, they start eliminating or losing the synaptic connections in the brain. So many people end up struggling with depression for long periods of time,. even with psychotherapy or medication treatments.

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