Episode 17 - Enough about DAT | Approach to DAT Negative Haemolysis
Bloody Minded
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Enzymatic Red Cell Disorders Explored
This chapter focuses on enzymatic red cell disorders, primarily G6PD deficiency and pyruvate kinase deficiency, and their mechanisms leading to oxidative hemolysis. It discusses key indicators such as bite cells and Heinz bodies, highlights the role of fava beans in hemolytic episodes, and touches on the complexities of hemoglobin disorders and DAT-negative hemolysis. Intrinsic and extrinsic factors causing red cell destruction are examined, along with microangiopathic processes and the implications of various conditions including Wilson's disease and March hemoglobinuria.
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