Is the Forcible Calorie Deficit a New Normal?

If we put the mice or rats on a forced calorie deficit, they'll lose weight up to a certain point and then they stop. It still takes 30 to 40 days for them to come back into balance. In these studies, they don't keep adjusting it down because obviously the mouse or the rat would die,. That never becomes the new normal. If you give them the opportunity to go back and eat what they were eating before, they always take that opportunity.