REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?
REBEL Cast
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The ProCoAG Trial on Four Factor PCC and Trauma Patients
There's been three previous trials on four factor PCC and trauma patients. They can only say that there was an association, not causation, but they just weren't powered well enough to tell us about these thromboembolic events. This is really important that we get this kind of literature done, Slem says.
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Background: Hemorrhage is the leading cause of mortality in trauma patients. Interventions such as early application of hemorrhage control, tranexamic acid, reduction of crystalloid fluid administration and balanced ratio blood product transfusion have improved many patients’ outcomes. However, mortality still remains high due to trauma-induced coagulopathy. Some clinicians have advocated for early administration of 4-factor ... 
