Low IGF-1 Is Not a Problem

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I wanted to ask you about low IGF-1 because I had come across a few papers suggesting that it was associated with greater risk of cognitive decline. But what's going on here? Why is low IGF- 1 potentially a problem? And this is why we say the devil is in the details, and so we already know very, very well that low IGF-one doesn't cause a problem. Low IGF-1 is the consequence of the problem. Can you become resistant to the effect of IGF-1? Yeah, there was a number of papers showing IGF-1 resistance.

Episode #237. Dr Valter Longo introduces intriguing questions to the show: could protein consumption actually be harmful to our health? How important is muscle tissue? Can fasting be used as an adjunct cancer treatment? We investigate these questions and many more, diving into the research on IGF-1, mTOR, and the fasting-mimicking diet.

Specifically, we discuss:

Intro (0:00)
Ideal diets for longevity (2:58)
Important Pathways for aging (9:15)
IGF1 Elevation (16:24)
Actue vs Chronic elevation of IGF1 (19:46)
Danger of Protein Over Consumption (25:11)
Impact of exercise on IGF1 (32:52)
Muscle Mass and Longevity (38:35)
Study on High Protein Later in Life (41:59)
How to get IGF1 tested (48:03)
Low IGF1 & Cognitive Decline (49:54)
Resistance to IGF1 (53:00)
Mendelian Randomization Studies (54:38)
Fasting Mimicking Diet (59:21)
Fasting and Cancer (1:16:03)
Ketogenic Diet & Cancer (1:27:51)
Outro (1:32:15)

To connect with Dr Valter Longo, you can find him on Instagram and Facebook. Learn more about Dr Longo’s research on his website, https://www.valterlongo.com/, where you will also be able to view and purchase his book, The Longevity Diet. Make sure to listen to Dr Longo’s previous appearance on The Proof, Episode #106.

Discover supporting studies and more insights in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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