Sharding can be challenging due to one-off cases where a single customer or subset of customers is much larger than others, leading to difficulties in fitting into the standard sharding scheme. However, it is possible to address this issue by selectively choosing which shard specific items are on, such as the case of Justin Bieber having his own complete stack to run his Instagram account. This flexibility in sharding allows for isolating workloads and avoiding noisy neighbor issues that can impact the entire server, as seen with the example of a heavily starred repo like Bootstrap on GitHub.

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