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The Curbsiders Internal Medicine Podcast cover image

#321 Hypertension FAQ: Common Outpatient Cases with Dr. Jordy Cohen

The Curbsiders Internal Medicine Podcast

NOTE

Chlorthalidone dosing and the potential for every other day use in patients

Chlorthalidone, a tiny pill with a long half-life, is often prescribed to patients. Breaking it in half is difficult but not necessary as even one-third or two-thirds of a pill can provide a steady effect due to its long-acting nature. It is recommended to convince generic drug companies to sell a 12.5 milligram pill. Some patients have successfully taken a 25 milligram pill every other day. Overall, chlorthalidone's extended-release properties allow for flexible dosing.

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