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Does the Evidence Now Support Effective Reps? Ft. Greg Nuckols | Ep. 58

Data Driven Strength Podcast

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Challenges in Predicting Muscle Size Change and Understanding Hypertrophy Mechanisms

The prediction intervals for the model span from negative 1% to plus 20%, indicating the uncertainty in the relationship between proximity to failure and hypertrophy. The state of the literature shows that outcome data is not always clear and precise, leading to many open questions in understanding mechanistic aspects of hypertrophy. Investigating mechanisms of hypertrophy is challenging due to the dynamic nature of cells in living creatures and the limitations in investigating certain processes unless tissue is removed.

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