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How Placebo Effects Work to Change Our Biology & Psychology

Huberman Lab

NOTE

The Surprising Effects of Placebo Drugs on Dopamine Release

Racletride, a substance similar to dopamine, was used in a study on the effects of placebo drugs. The study revealed that the placebo caused reduced binding of racletride to dopamine receptors in the brain, indicating an increase in dopamine release. This increase in dopamine levels occurred because the dopamine receptors were already occupied by the released dopamine, preventing racletride from binding. The findings suggest that placebo drugs, although not directly affecting the dopaminergic system, can lead to increased dopamine levels in the brain, potentially impacting conditions like Parkinson's disease.

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