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Omega-3 vs Omega-6: The Ultimate Guide to Essential Fatty Acids | A Masterclass

The Proof with Simon Hill

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The Dual Impact of Polyunsaturated Fatty Acids on Cardiovascular Health

Polyunsaturated fatty acids (PUFAs), particularly omega-3 and arachidonic acid, play a crucial role in cardiovascular health through their diverse effects on various physiological aspects. An adequate antioxidant diet enhances the beneficial impacts of PUFAs, whereas a poor diet may hinder these effects. Inflammation, cholesterol levels, and blood clotting are key cardiometabolic risk factors influenced by PUFAs. Arachidonic acid promotes blood clotting, while omega-3 fatty acids exhibit an anti-thrombotic action that may reduce mortality from coronary heart disease, highlighting the importance of balance between these fatty acids. Moreover, omega-3s positively affect heart physiology, cardiac rhythm, and heart rate variability, further promoting cardiac health. PUFAs also influence vascular function, impacting how blood vessels behave, potentially due to inflammatory mechanisms and other factors. Additionally, the role of PUFAs extends to individual tissues such as the liver and adipose tissue, where omega-3s contribute to metabolic homeostasis by promoting fatty acid oxidation and reducing triglyceride synthesis.

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