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Microbial Influence Shapes Personalized Medicine
The impact of the hundred trillion microbes residing in the mouth and gut is crucial in understanding personal health and treatment responses. Identical twins have been shown to react differently to the same food, highlighting that genetic similarity alone does not account for variations in health outcomes; microbial diversity plays a key role. As the development of digital twins of human biology progresses, including the microbial ecosystem, personalization in medicine will advance significantly. This could revolutionize drug efficacy, as demonstrated by the contrasting effects of medications like Labdopa for Parkinson's, which can be nullified by certain gut microbes. Furthermore, combinations of probiotics with drugs like metformin have shown enhanced effects, indicating that microbiome activity can predict treatment outcomes such as HBA1c reduction. Recognizing and integrating the microbiome into health strategies will pave the way for tailored medical solutions.