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The Peter Attia Drive cover image

#316 - AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations

The Peter Attia Drive

NOTE

Genetic Vulnerability Meets Hormonal Influence

Genetic susceptibility, when combined with hormonal factors, leads to hair follicle miniaturization and thinning over time due to shrinking follicles. Both men and women produce testosterone, which is converted into dihydrotestosterone (DHT), a more potent hormone with a significantly higher binding affinity for androgen receptors. DHT's strong interaction with hair follicles is critical in the miniaturization process implicated in androgenic alopecia. The primary cause of baldness is likely not increased DHT production, but rather the varying sensitivity of hair follicles to DHT, suggesting that genetic differences in receptor sensitivity are more crucial than differences in DHT generation itself.

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