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GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
Huberman Lab
**REM sleep shuts off noredrenaline on brain and acelticoln goes up **
During REM sleep, a significant alteration in brain chemistry occurs, characterized by the complete shutdown of noradrenaline (also known as norepinephrine) and a reduction in serotonin levels. In contrast, acetylcholine, another neurotransmitter, experiences a substantial increase, with levels rising by nearly 30% in certain brain regions compared to wakefulness. This indicates that acetylcholine may play a crucial role in facilitating REM and dream sleep, while the blockade of noradrenaline highlights its association with stress-related neurochemicals, emphasizing the unique neurochemical environment during this sleep phase.
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