4min snip

The Tim Ferriss Show cover image

#766: The Random Show — Lessons from Tim’s Sabbatical, Alzheimer's Breakthroughs, Kevin Tries a Medium, Fitness Tools and Protocols, Book Recommendations, and More

The Tim Ferriss Show

NOTE

Exercise: The Key to Clotho and Cognitive Resilience

Clotho, a protein that influences cognitive function and longevity, is produced naturally in humans, particularly during high-intensity exercise. Genetic factors, specifically certain SNPs, can affect the risk of developing dementia; for example, carriers of the ApoE4 gene variant have significantly higher Alzheimer's risk. However, those who overproduce clotho due to favorable genetic polymorphisms can mitigate this risk. Research involving various animal studies, including monkeys, shows that boosting clotho levels can lead to remarkable cognitive enhancements. Before therapeutic treatments become available, regular exercise remains one of the most effective methods to increase circulating clotho levels, underscoring its importance in brain health and resilience.

00:00

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode