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Video Episode | Mr. Happy | The Next Generation - Part 2

In Search of Insight

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Imbalance Breeds Dependence

Activation of the endogenous opioid biosynthesis pathway occurs through the interaction of dopamine and DOPAL. Disruptions to aldehyde dehydrogenase activity can lead to the accumulation of DOPAL, diverting metabolic processes towards morphine production. Factors like low levels of NAD or essential minerals can inhibit this enzyme, resulting in chronic morphine production akin to prolonged narcotic use. This chronic production causes downregulation of receptors and pathways, leading to long-term homeostatic imbalances that persist even after the initial disruption is resolved, necessitating a recovery period for the system to reset.

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