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GUEST SERIES | Dr. Matt Walker: The Biology of Sleep & Your Unique Sleep Needs
Huberman Lab
Sleep Deprivation Diminishes Immune Defense against: cancer, flu, heart attack, VO2
Sleep deprivation significantly impairs immune function and increases health risks. Studies reveal that just one night of limited sleep (four hours) can lead to a staggering 70% reduction in natural killer cell activity, critical for combating cancer. Insufficient sleep prior to vaccination adversely affects antibody production, with individuals producing less than 50% of the normal response to flu shots, rendering them less effective. Chronic sleep deprivation (less than six hours nightly) is linked to nearly threefold increased risks of common illnesses, like colds and flu. Additionally, the cardiovascular system is compromised due to lack of sleep, with research indicating a notable increase in heart attack risk following sleep loss events, such as daylight savings time, which correlates with a 24% spike in heart attack rates when losing an hour of sleep. Conversely, gaining an hour in the fall leads to a 21% decrease in heart attack occurrences. Overall, these insights demonstrate the profound impact of sleep on both immune defenses and cardiovascular health.
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