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#56, Alex Zhavoronkov and the GenAI Revolution in Drug Discovery at Insilico Medicine

AWS Health Innovation Podcast

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The Challenges of Hypothesis Validation and Preclinical Stages in Drug Development

Generating a molecule that hits the target is a challenging process. Most hypotheses fail and are validated using cell based models. The failure rate is high, ranging from 95 to 99%. One approach is to remove a gene from a mouse and observe if it exhibits a desired phenotype. The development of molecules to hit the target is a costly process, often resulting in failure. There are six preclinical stages before a candidate is ready for human trials. One of these stages involves conducting long-term GLP safety studies, following specific standards.

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