Antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs), require a significant amount of time to exhibit their effects, typically ranging from one week to eight weeks. Unlike substances like alcohol, which provide immediate effects, SSRIs work by activating cellular machinery and genes that produce neuroprotective proteins in the brain over time. This gradual process means individuals may not experience immediate relief from depression or notice positive outcomes right after starting the medication. In contrast, side effects such as nausea can manifest quickly, reminding patients to remain patient and committed to the medication regimen despite initial discomfort.