Harnessing the Power of Mild Stress for Mitochondrial Rejuvenation

Mild stressors like fasting can stimulate beneficial effects through the hormesis principle, promoting mitochondrial health. These stresses can lead to increased production of superoxide, which may cause mitochondrial rejuvenation and activation of essential proteins like PGC1 alpha. The process can also initiate a response to unfolded proteins within mitochondria, enhancing gene expression related to mitochondrial function. Molecular hydrogen plays a valuable role in this context, as it can trigger reverse electron transport and improve mitochondrial biogenesis and functionality. Ultimately, these mechanisms contribute to optimal energy production and cellular resilience.