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GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation

Huberman Lab

NOTE

REM sleep as overnight therapy, amygdala and hippocampus active on safe conditions

REM sleep creates a neurochemically safe environment conducive to emotional therapy. During this phase, the levels of noradrenaline and serotonin decrease, while acetylcholine levels increase significantly—up to 30% higher in some brain regions compared to wakefulness. This alteration in neurotransmitter activity allows the hippocampus and amygdala, key centers for memory and emotion, to remain active. As a result, REM sleep provides an optimal condition for individuals to reactivate and process emotional memories, facilitating a form of emotional regulation without the intensity of emotion that typically accompanies these memories in waking life.

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