Response to antidepressant medication varies significantly among individuals with depression, revealing three distinct groups. Approximately one-third of patients experience substantial benefits, showing 70% to 90% improvement, effectively alleviating their symptoms. Another one-third find moderate relief, achieving a 30% to 50% improvement that does not fully alleviate their depression. The final third shows little to no response to treatment, particularly when their depression is linked to circumstantial or existential crises, such as job loss or broader societal issues. This highlights the complexity of depression, suggesting that antidepressant efficacy may depend on the specific nature of the individual's depression.