Optimal Dosing Parameters for Methylene Blue

Optimal dosing parameters for methylene blue experimentation range between 40 to 80 milligrams per day, potentially reaching up to 500 milligrams in certain cases, which has been validated in various studies. Caution is advised when combining methylene blue with SSRIs or other serotonin-affecting substances due to the risk of serotonin storm, based on historical cases involving high doses and thymus gland surgery. Recent reviews have clarified that such warnings are specific to extreme cases and not general use, indicating the missed potential of methylene blue as a therapy for depression.