Based on genetic information, we can predict if someone's LDL cholesterol will be high or low. If their genetics predict low LDL but their measurements are high, lifestyle changes can lower their cholesterol. However, if their genetics predict high LDL and their measurements are already high, lifestyle changes have no significant effect. This was shown in a study where the bottom 40% with low-predicted LDL saw significant cholesterol reduction, while the top 40% with high-predicted LDL saw no change. This example demonstrates the impact of genetics on cholesterol levels.

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