Supplementing with arachidonic acid may increase inflammation-related compounds, but since our cells already have high levels due to omega-6 intake, the impact of supplementation is minimal. On the other hand, EPA and DHA supplements can significantly reduce arachidonic acid in cell membranes, potentially explaining the anti-inflammatory effects of omega-3s. Research gaps exist in understanding the effects of reducing arachidonic acid intake through diet manipulation compared to increasing it through supplements.

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