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#85 – Who You Gonna Call? Mythbusters! Antibiotic Myths for Infectious Diseases Clinicians
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Rethink the Myths of Antibiotic Efficacy
Training and past studies often perpetuate the myth that trimethoprim-sulfamethoxazole (Bactrim) is ineffective against group A streptococcus (strep pyogenes). However, while older data questioned its efficacy for pharyngitis and rheumatic fever, recent clinical evidence shows Bactrim is indeed effective for skin and soft tissue infections, including abscesses and cellulitis caused by strep. Despite concerns, patients treated only with Bactrim demonstrated successful outcomes in clinical studies, emphasizing a need to reevaluate outdated perceptions. Nonetheless, caution is warranted as these findings do not apply to more severe infections, such as necrotizing fasciitis or invasive bacteremia, where more potent alternatives are necessary.
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