In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast.
We each present a peer-reviewed scientific paper chosen because it contains novel, interesting, and actionable data. First, we discuss a paper on how bright light exposure at sunrise and throughout the day and dark exposure at night independently improve mental health and can offset some of the major symptoms of mental health disorders such as depression and anxiety. Then, we discuss an article that explores a novel class of immunotherapy treatments to combat cancer. We also discuss some of the new data on low-calorie sweeteners and if they are safe. This episode should be of interest to listeners curious about maximizing their vitality and longevity and to anyone seeking science-supported ways to improve mental health and lifespan.
Read the full shotes for this episode at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
LMNT: https://drinklmnt.com/hubermanlab
Timestamps
00:00:00 Dr. Peter Attia, Journal Club
00:02:56 Sponsors: LMNT & Waking Up
00:07:14 Light, Dark & Mental Health; Retina
00:11:16 Outdoor vs. Indoor Light, Cataracts, Sunglasses
00:16:17 Tools: Sunrise & Sunsets, Circadian Rhythm; Midday Light
00:24:55 Tools: Night & Light Exposure; Waking Before Sunrise
00:31:05 Article #1, Light/Dark Exposure & Mental Health
00:32:36 Sponsor: AG1
00:38:18 Odds Ratio, Hazard Ratio
00:45:43 Night vs. Daylight Exposure, Mental Health Disorders
00:51:35 Major Depression & Light Exposure; Error Bars & Significance
01:00:39 Prescriptions; Environmental & Artificial Light; Red Lights
01:08:14 Nighttime Light Exposure; Sleep Trackers & Belief Effects
01:13:54 Light Directionality, Phone, Night
01:17:21 Light Wavelengths & Sensors; Sunglasses
01:20:58 Hawthorne Effect, Reverse Causality, Genetics
01:26:26 Artificial Sweeteners, Appetite
01:31:16 Natural Light Cycles, Circadian Rhythm & Mental Health
01:39:53 Article #2, Immune System & Cancer
01:43:18 T-Cell Activation; Viruses
01:50:41 Autoimmunity; Cancer & Immune System Evasion
02:00:09 Checkpoint Inhibitors, CTLA-4
02:06:45 Anti-CTLA-4 Study Drug Ipilimumab, Melanoma
02:12:07 Patient Population, Randomization, GP100
02:18:09 Response Rate
02:22:52 Overall Survival & Response
02:28:38 Median Survival vs. Overall Survival, Drug Development
02:35:45 Gender & Dose
02:40:32 Adverse Events; Autoimmunity
02:46:42 Pancreatic Cancer; Aging & Immune System Health
02:53:57 Melanoma; Lynch Syndrome, Keytruda
02:58:43 Immunotherapy & Cancer Treatment; Melanoma Risk
03:06:26 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
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