The key insight is that when facing challenging colleagues at work, it is essential to understand that trying to change others is not effective. The focus should be on changing oneself or the environment. Persisting in a negative situation can lead to long-term health issues. It is crucial to prioritize one's well-being by either adapting to the situation without letting it affect mental health or making changes, either within oneself or in the surroundings. Simply changing jobs may not solve the underlying issue as it stems from internal conflicts. Self-mastery is emphasized as a way to address challenges by introspectively identifying and resolving conflicts within oneself, leading to personal growth and development.

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