Metabolic health truths | Christos Mantzoros MD, DSc, PhD
The Proof with Simon Hill
Metabolic Conditions and Fat Storage
Metabolic conditions arise from storing fat in the wrong place, such as in the liver or vasculature. When excess fat accumulates in the liver beyond a certain percentage, the body triggers an inflammatory response involving macrophages to remove the fat through phagocytosis, as the body is designed to defend its physiology.
Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones.
You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease.
Specifically, we discuss:
- Introduction to The Latest Obesity Research Findings (00:00)
- The Evolving Understanding of Obesity Science (03:49)
- Uncovering New Fat Storage Mechanisms (10:57)
- Modern Techniques for Accurate Body Fat Measurement (15:02)
- Why Maintaining Weight Loss Is So Challenging (20:01)
- Evolutionary Insights into Human Fat Storage (25:12)
- How Leptin Regulates Energy Balance and Health (29:17)
- New Approaches to Break Through Weight Set Points (39:27)
- Environment's Role in Weight Gain Beyond Diet (45:49)
- Decoding the Genetics of Fat Storage and Metabolism (52:59)
- Non-Alcoholic Fatty Liver Disease Explained (55:40)
- Evidence-Based Nutrition for Optimal Liver Health (01:05:25)
- Promising Advances in Non-Invasive Liver Tests (01:10:49)
- Oestrogen's Impact on Metabolism (01:20:14)
- The Link Between Liver Fat and Insulin Resistance (01:22:04)
- Addressing America's Growing Metabolic Health Crisis (01:26:11)
- Outro (01:27:11)
Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here.
This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book
Remember Everything You Learn from Podcasts
