Zonulin as a Marker of Intestinal Permeability

There’s still a lot we don’t understand about the science of leaky gut. Does it cause disease or is it a symptom? What’s the best way to test for it? Which treatments actually work to repair it? 

Today’s guest is one of the best people to begin to answer these questions. 

Dr. Camilleri is a renowned gastroenterology researcher and professor at the Mayo Clinic. 

Tune in to hear about cutting-edge innovations and informed understandings around leaky gut testing and treatment. 

If you have any additional questions you would like answered in the future, let me know in the comments!

 

Watch/Read Next…

• What is Leaky Gut: https://drruscio.com/what-is-leaky-gut/ 

• Leaky Gut Suplements: https://drruscio.com/leaky-gut-supplements/ 

• Probiotics for Stomach Issues: https://drruscio.com/probiotics-for-stomach 

• Learn more about Dr. Camilleri’s work: https://www.mayo.edu/research/faculty/camilleri-michael-m-d-d-sc/bio-00026245 

 

Timestamps

00:00 Intro 

03:25 Dr. Camilleri’s background with leaky gut

05:05 Bile-acid supplementation 

07:20 The small intestine 

11:07 The prevalence of leaky gut 

14:25 Leaky gut & diseases

20:08 Leaky gut & inflammation

30:18 Treatment: Where to start 

36:09 Biomarkers of leaky gut

48:53 Leaky gut testing 

53:24 Gluten intolerance prevalence 

59:52 Food elimination & reintroduction 

01:04:47 Prebiotics & FODMAPs

01:15:26 Probiotics

 

Featured Studies 

• What to do about the leaky gut: https://pubmed.ncbi.nlm.nih.gov/34509978/

• Leaky gut: mechanisms, measurement and clinical implications in humans: https://pubmed.ncbi.nlm.nih.gov/31076401/

• Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults: https://pubmed.ncbi.nlm.nih.gov/33865841/ 

• A case for improved assessment of gut permeability: a meta-analysis quantifying the lactulose:mannitol ratio in coeliac and Crohn's disease: https://pubmed.ncbi.nlm.nih.gov/35012471/ 

• Food Emulsifiers and Metabolic Syndrome: The Role of the Gut Microbiota: https://pubmed.ncbi.nlm.nih.gov/35892789/

• Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease: https://pubmed.ncbi.nlm.nih.gov/33336247/

• Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity: https://pubmed.ncbi.nlm.nih.gov/32060130/

• Psychological and Gastrointestinal Symptoms of Patients with Irritable Bowel Syndrome Undergoing a Low-FODMAP Diet: The Role of the Intestinal Barrier: https://pubmed.ncbi.nlm.nih.gov/34371976/ 

• Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials: https://pubmed.ncbi.nlm.nih.gov/37168869/ 

• Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome: https://pubmed.ncbi.nlm.nih.gov/30108163/ 

 

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DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g 

*Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.