The notion that weight loss induces muscle mass loss is a misconception. The level of muscle loss is consistent with any calorie-restricted diet or bariatric surgery. Protecting muscle involves prioritizing protein macros, strength training, and addressing malnutrition. Lean mass loss includes various soft tissues, not just muscles. GLP-1 agonists may contribute to lean mass loss by reducing fatty infiltrates in the liver, pancreas, and muscles of individuals with obesity or metabolic issues.

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