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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity

Huberman Lab

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Neural Circuit Changes in Response to Ketamine and Mental Health

Discussion of neural circuit changes in response to ketamine is essentially a process that shifts the overall system towards further changes in response to daily activities, ultimately enhancing mental health. Ketamine doesn't just provide relief for clinical challenges in a singular manner due to the complexity of mental processes, like depression, which involve both pro-depressive and anti-depressive circuits. Evidence shows that ketamine treatment can dampen the output from the habenula to the reward pathway, diminishing negative influences and making the reward pathway more accessible for engaging in anti-depressive thoughts and behaviors. Moreover, ketamine can also enhance neuroplasticity within the reward pathway by strengthening connections with the frontal cortex.

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