#529: Addressing Popular Claims About Cholesterol, Dietary Fat and Heart Disease
Sigma Nutrition Radio
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LP little a as a Causal Biomarker for Cardiovascular Disease
LP little a is likely to be declared as the second causal biomarker for atherosclerotic cardiovascular disease. Although it shares similarities with LDL, it has distinct characteristics, primarily influenced by genetics rather than diet. Current major LDL lowering drugs do not target LP little a directly. Evidence supporting its role as a causal biomarker comes from a graded linear temporal relationship in population research, mechanistic evidence, and intervention trials. While there is potential for it to become a target for treatment, the specific agents for targeting it are still under development.
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