Importance of Extra Virgin Olive Oil in Dietary Intervention Studies

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In a study called Freddie Med, participants were divided into three groups: a control group advised to eat a low-fat diet but consumed 37% fat, an olive oil intervention group given a liter of olive oil per week, and a mixed nuts group. The difference in olive oil consumption between the control and intervention groups was just one tablespoon per day. Notably, the intervention group consumed extra virgin olive oil, which contains a polyphenol called hydroxy tyrosol absent in refined olive oil. This distinction is crucial as studies show refined olive oil can increase lipogenic enzymes significantly. Although the Freddie Med study faced initial retraction due to randomization issues, it was swiftly republished, claiming a nearly 30% reduction in mortality over five years due to just a one tablespoon difference in olive oil consumption per day, raising doubts about the validity of such remarkable results.

On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins

00:02:50 Brad’s weight loss journey

00:10:50 The human metabolism

00:15:10 How olive oil makes us fat

00:34:24 Deep dive into European diets

00:48:50 PREDIMED trial comparing different types of olive oil

00:51:05 De novo lipogenesis (DNL)

00:53:50 What happens when humans eat canola oil

00:59:20 A story about the Inuit & long-term ketosis

01:07:20 Takeaways about olive oil

Connect with Brad:

https://www.youtube.com/@fireinabottle3410

References:

Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence

Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004

OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext

Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/