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Dan Garner: Objective Measures, Patterns, and the Art in Biomarkers

The Ready State Podcast

NOTE

Questioning Reference Ranges for Biomarkers and Optimal Health

Reference ranges for biomarkers may not reflect optimal health, particularly for athletic individuals. Standard reference ranges for biomarkers like ferritin may not cater to the needs of athletes who may require higher levels for optimal performance. The discrepancy in reference ranges could lead to misinterpretation of health status and potential risks. For instance, observed values within the normal reference range can still pose significant health risks, such as cardiovascular issues, hypertension, oxidative stress, and deficiencies in essential nutrients like folate and B12. This discrepancy may lead to individuals being unaware of potential health risks flagged by their biomarker levels. The current approach to establishing reference ranges using a bell curve model may not capture optimal physiological functioning, especially as population health deteriorates. Therefore, there is a need to reconsider how reference ranges are determined to better reflect optimal health and provide individuals with the option to optimize their biomarker levels.

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