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#074 Dr. Dominic D'Agostino on Developing a Well-Designed Ketogenic Diet and Harnessing Its Benefits

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Benefits of Ketogenic Diet and Ketone Esters

The ketogenic diet has therapeutic and beneficial effects that do not occur with exogenous ketones. However, there is significant overlap. Administering ketone esters and salts to animals not on the ketogenic diet produced anti-cancer effects and changed brain neuropharmacology by increasing GABAergic tone. The conversion of glutamate to GABA through glutamic acid decarboxylase stabilizes and calms the brain. Animal models also showed silenced seizures with the ketogenic diet in cases of Angelman syndrome.

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