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REPLAY: Fibromyalgia: Central Sensitisation, Brain Architecture and the Pain Matrix with Dr. Michelle Woolhouse and Dr. Lily Tomas

FX Medicine Podcast Central

NOTE

Mitochondrial Dysfunction in Fibromyalgia

Mitochondrial dysfunction in fibromyalgia triggers increased glutaminergic transmission leading to neuroinflammation, which contributes to peripheral muscle pain and central pain sensitization. Pro-inflammatory cytokines expression in fibromyalgia is both dependent upon and elevated by mitochondrial dysfunction and oxidative stress. Moreover, impaired mitochondrial functioning has been linked to damage to the axons of nerve cells, potentially causing allodynia, a characteristic symptom of fibromyalgia.

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