Clotho: The Guardian of Youth and Cognition | 1min snip from The Tim Ferriss Show

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#766: The Random Show — Lessons from Tim’s Sabbatical, Alzheimer's Breakthroughs, Kevin Tries a Medium, Fitness Tools and Protocols, Book Recommendations, and More

The Tim Ferriss Show

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Clotho: The Guardian of Youth and Cognition

Clotho is a compound identified as crucial in maintaining cognitive health, primarily recognized through research led by Lydina at UCSF. Natural production of Clotho increases with high-intensity exercise but decreases with age. Genetic variations can influence the levels of Clotho; individuals who produce it in higher quantities exhibit significantly lower risks of dementia, even when factoring in other genetic risks such as those posed by the ApoE3 gene. This compound holds promise as a key component in understanding and potentially mitigating cognitive decline as humans age.

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This time, we have a very special episode I recorded with my close friend Kevin Rose in person at his house. We trade our latest discoveries, and I think it’s one of our best. Tons of actionable takeaways and laughing fits. We cover dozens of topics: new projects, what I’ve done on my recent sabbatical after the podcast’s 10th anniversary, Kevin’s latest findings and shenanigans, real vampire protocols, and much, much more.

Sponsors:

Helix Sleep premium mattresses: https://HelixSleep.com/Tim (25% off all mattress orders and two free pillows)

AG1 all-in-one nutritional supplement: https://drinkag1.com/tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)

Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 5.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.

Timestamps:

[00:00] Start

[07:40] A sabbatical recap and future podcasting plans.

[15:25] PicStudio's disturbingly realistic AI-generated portraits.

[17:25] Kevin's new Jess Mascetti tattoo.

[18:08] Vampire facials and a platelet-rich plasma (PRP) problem.

[22:22] Tequila martinis.

[24:20] Romance versus radical planning.

[32:50] Bobby Fingers.

[34:46] Training for the hunt.

[41:15] Fairbanks fun.

[42:11] European dating.