The speaker emphasizes the importance of assessing plaque presence in areas such as the carotid and coronary arteries rather than focusing solely on biomarker levels like ApoB or lipoprotein status. They prioritize looking for coronary plaque, carotid plaque, microvascular ischemic plaque, and peripheral artery disease to determine the risk, suggesting that getting a baseline assessment around the age of 40 through CCTA can be valuable.
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