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#311 ‒ Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more
The Peter Attia Drive
Preventing Ischemic Cardiovascular Disease: Insights and Strategies
Preventing ischemic cardiovascular disease requires a multi-faceted approach that emphasizes reducing apo B particles, protecting the endothelium, and managing inflammation. A lower number of apo B particles corresponds to a decrease in atherosclerotic cardiovascular disease (ASCVD), supported by strong evidence from experimental data, clinical trials, and epidemiologic research. Protecting the endothelium is crucial, as factors like smoking, high blood pressure, and metabolic conditions associated with insulin resistance contribute to endothelial vulnerability. Elevated glucose, insulin, and metabolic byproducts weaken the endothelium, increasing cardiovascular risk alongside high apo B levels. While inflammation also plays a role, it is less directly manageable through pharmacologic treatments compared to the first two factors. Interventions to improve nutrition, sleep, and exercise contribute to managing inflammation. Despite the prevalence of cardiovascular disease as a leading cause of death globally, it remains largely preventable through these targeted strategies.
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