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Methylate Your Way to Mental Health With Dopamine | Mastering Nutrition #34

Mastering Nutrition

NOTE

The Effects of Extreme Over-methylation on Dopamine Levels

In an extreme over-methylation state, excessive methylation of dopamine can occur./nDopamine is metabolized by COMT and primarily governed by reuptake and oxidation./nThere is some interaction between monomynoxidase activity and the tonic pool of dopamine, as well as between COMT activity and the phasic pool./nMethylation typically affects the tonic pool of dopamine, but excessive methylation can deplete dopamine levels overall.

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