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Preventable Chronic Diseases and the Role of the Microbiome
Chronic diseases like obesity, diabetes, depression, and others are not infectious but develop over time due to changes in the microbiome. Studies show that the microbiome can cause symptoms to manifest not only within species, but also across different species. This was demonstrated through fecal transplants from humans to mice, resulting in the mice developing the same characteristics as the human donors. Obesity is identified as an inflammatory disease and not simply a consequence of overeating. A leaky gut due to compromised epithelial cells can lead to inflammation, allergies, and other health issues. Fecal transplants are used to restore a healthy microbiome in individuals who have had their microbiome compromised through factors like antibiotic use or conditions like C. difficile infection. The impact of the microbiome is evident in various diseases such as Parkinson's, depression, autoimmune diseases, cancer, and diabetes. Metformin, a drug for diabetes, was found to work on the microbiome rather than directly on the human body, as evidenced by its effects on mice with diabetic microbiomes. Ultimately, fixing the gut microbiome can have a broad impact, addressing not only the condition that prompted the treatment, but also other related inflammatory diseases.