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Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity
Huberman Lab
The Role of Ketamine in Depression
Ketamine and PCP share a similar mode of action as dissociative anesthetics in the brain. Ketamine is being recognized for its benefits in treating depression, suicidality, and PTSD when administered in appropriate dosages and frequency. However, it also has a high potential for abuse, leading to recreational use and addiction. Despite its historical association with street drugs, ketamine has gained prominence in clinical settings for the treatment of mental health conditions like depression, particularly in the last five to ten years. This shift in perception is attributed to evolving understanding of depression and its treatments, moving away from the traditional monoamine hypothesis that dominated the mid-20th century.
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