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#515: Does Dietary Fat Quality Causally Affect Atherosclerosis Risk? – Jacob Christensen, PhD

Sigma Nutrition Radio

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Lowering LDL Cholesterol and ASVD Risk

Lowering LDL cholesterol through drugs like HMG-A-CoA reductase inhibitors has been extensively studied in over half a million participants for many years, showing a consistent pattern of reduced ASVD risk. Various interventions such as PCSK9 inhibitors, bile acid sequestration, and dietary treatments also lower LDL cholesterol and ASVD risk. Studies reveal that a one millimolar reduction in LDL cholesterol over five years translates to a 23% lower ASVD risk, and a 30% lower risk over 12 years. Mendelian randomization studies with a 52-year follow-up indicate a 50% lower ASVD risk, emphasizing not just the exposure but also the duration of exposure as crucial for risk reduction.

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